ABSTRACT
Background: The prevalence of HIV among the adult population has continued a steady decline at the national level from an estimated peak of 0.4% in 2000 down to 0.26% in 2015. The data generated by ICTC may provide important clues to understand the epidemiology of the disease in a specific area, as well as pattern of risk behavior of the population.Methods: The present retrospective record based cross sectional study was carried out at the ICTC Centre of SDM College of Medical Sciences and Hospital, Dharwad. Retrospective data for the past six years (2012-13 to 2017-18) on clients visiting the ICTC was collected from the ICTC registers.Results: A total of 45,066 clients attended the ICTC over a period of 6 years, among which 61.6% were females and 38.4% were males. Among the total females, 55% were antenatal mothers. Out of the total clients tested, 99.75% of clients underwent post-test counseling. Among the total clients, 669 were HIV sero-positive clients out of which majority (61.7%) were males. The total positivity rate was 1.48% among the ICTC attendees. 47 clients had co-infections with TB.Conclusions: The challenge is to increase access to and uptake of HIV testing priority. Intense IEC activities for behaviour change at grass root level populations should be encouraged.
ABSTRACT
CONTEXT: Clindamycin is one of the important alternative antibiotics in the therapy of Staphylococcus aureus, particularly in methicillin-resistant S. aureus (MRSA) infections. Inducible clindamycin resistance (iMLS B--inducible Macrolide-Lincosamide-Streptogramin B resistance) is a critical factor in antimicrobial susceptibility testing. AIMS: To know the rate of inducible clindamycin resistance among clinical isolates of Staphylococcus aureus in our hospital by Disk approximation test (D-test) using the average recommended inter-disk distance and comparing the results with that of D-test using the lower limit of recommended inter-disk distance. MATERIALS AND METHODS: A total of 51 erythromycin-resistant and clindamycin-susceptible S. aureus isolates were subjected to disk approximation testing with 21 +/- 1 mm and 15 mm edge-to-edge distance between the clindamycin and erythromycin disks. STATISTICAL METHODS: Z-test levels. RESULTS: Among 51 erythromycin-resistant and clindamycin-susceptible S. aureus isolates, 25 (49%) were recorded as inducible clindamycin resistant by D-test with 21 +/- 1 mm edge-to-edge distance between the clindamycin and erythromycin disks. When we re-tested all the 51 strains by D-test with 15 mm inter-disk distance, we identified 14% more iMLS B strains previously reported as D-test negative. Z-test for MRSA indicates that 15 mm edge-to-edge distance has significant advantage. CONCLUSIONS: Since the incidence of inducible clindamycin resistance is high (63% in our study), accurate identification of inducible clindamycin resistance is important to prevent therapeutic failure in infections caused by these strains. We suggest the use of D-test with 15 mm edge-to-edge inter-disk distance for detecting iMLS B .